MDM2(12q15)/CEN12 FISH Probe Kit
MDM2(12q15)/CEN12 FISH Probe Kit
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Product No. Specification Probe Color
  • Detail
  • Parameters

1.MDM2 amplification occurs in a subset of patients with atypical lipomatous tumor/well-differentiated liposarcoma, particularly in small biopsy samples.


2.MDM2 and CDK4 amplifications are frequently observed in both dedifferentiated liposarcoma and well-differentiated liposarcoma.


3.Dedifferentiated liposarcoma with epithelioid or epithelial-like morphology is easily misdiagnosed as carcinoma or mesothelioma, and MDM2 amplification plays a crucial role in differential diagnosis.


4.Similar to ALT/WDL, they exhibit ring chromosomes or giant marker chromosomes with amplification of the 12q13-21 region. Most retroperitoneal dedifferentiated liposarcomas show MDM2 amplification.


5.When diagnosing subcutaneous ALT/WDL, it is essential to first rule out lipomas with similar morphological features, such as spindle cell lipoma, pleomorphic lipoma, chondroid lipoma, and cellular angiolipoma. Additionally, differential diagnosis should include neurofibroma, well-differentiated sclerosing liposarcoma, and sometimes low-grade MPNST. The frequent co-amplification of MDM2 and CDK4 in ALT/WDL can aid in differential diagnosis.

价格
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Entire product
RUO
Cargo number
JLB301002
Clinical application
Sarcomas
Product classification
Custom probe service
Service Details
Jinlu Fluorescence in situ hybridization ( Fluorescence In Situ Hybridization, FISH) Probe customization service.
Probe Customization Process
1) Customer's intention to provide FISH Probe Customization Service and related materials or literature in connection with Golden Charm 2) The Golden Talisman is designed according to the customer's r
Products received by clients
The product received by the customer is a prepared double-stranded DNA probe that can be used directly for FISH detection.
Quality assurance of customize
Jin lu Biotech Co., Ltd. has rich FISH probe manufacturing experience, a set of effective manufacturing process, can guarantee that the synthesized probe is the customer needs probe, and can be direct
Loci
12q15